Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment – the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy – from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.
Arun D. Singh (Editor)
This book – a conjoint effort of ocular oncologists, general oncologists, and pathologists – is a comprehensive source of authoritative information on the subject of ocular and adnexal lymphoma. It covers all aspects, including clinical features, classification, epidemiology, diagnostic evaluation, biopsy techniques, histology and molecular pathology, staging procedures, and treatment methods. Detailed information is provided on primary vitreoretinal and adnexal lymphomas and chapters are also included on rare variants such as T cell lymphoma and reactive lymphoid hyperplasia of the ocular adnexa. The emphasis throughout is on easy readability, and the layout ensures rapid retrieval of information. In order to convey fundamental concepts, numerous tables, clinical photographs, histopathologic microphotographs, and imaging studies (fluorescein and indocyanine angiograms, ultrasonograms, CT scans, and MR images) are included.
Arun D. Singh (Editor), Bertil Damato (Editor)
Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.
Jacob Pe’er (Editor), Arun D. Singh (Editor)
Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors are carefully explained, and treatment options are considered in detail.
Tamara T. Mouratova (Author)
This book is a concise guide to the epidemiology of ocular tumours. Beginning with the classification and pathology of ocular tumours, the following sections discuss the most common benign and malignant tumours in both children and adults. Each section examines the wide spectrum of factors, including age, gender and environment; that impact the development and incidence of ocular tumours, and mortality and survival rates; in different geographical areas worldwide. Key points * Concise guide to epidemiology of ocular tumours in children and adults * Discusses most common malignant and benign tumours * Examines human and environmental factors impacting incidence, development, mortality and survival rates of ocular tumours * Discusses variations in different geographical regions
Retinoblastoma: An Update on Clinical, Genetic Counseling, Epidemiology and Molecular Tumor Biology
This book is an excellent compilation of both clinical and basic science information that meets the needs of a young clinician and a researcher at the same time. It also has abundant information on recent advances and cutting-edge knowledge in intracellular molecular cross-talking of retinoblastoma protein with various cellular viral-like proteins.
Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome.
Current Concepts in Uveal Melanoma (Developments in Ophthalmology) [Hardcover]
M. J. Jager (Editor), L. Desjardins (Editor), T. Kivela (Editor), B. Damato (Editor)
Uveal melanoma is an aggressive form of cancer that can involve the iris, the ciliary body, and/or the choroid, which is the main location of this tumor. Patients often wish to be informed about treatment choices and the results of different approaches. Important current clinical questions are whether a biopsy should be taken of choroidal melanomas, what should be done with this biopsy, and whether high-risk patients should be screened regularly. This volume describes the clinical characteristics of uveal melanoma along with the different current techniques available for treatment, such as radioactive plaque treatment, proton beam therapy, and local tumor resection. Furthermore, techniques for taking biopsies and characterizing biopsy material are demonstrated. Future therapies such as anti-VEGF treatment and options for the treatment of metastases are also discussed. Residents with an interest in ocular oncology, ophthalmologists or physicians dealing with uveal melanoma, as well as patients wishing to know more about this malignancy will find a topical update on uveal melanoma in this publication.
Jay Justin Older
Eyelid Tumors was written to help the physician diagnose eyelid tumors in the clinical setting and to assist the surgeon who might wish to remove the tumors and repair the eyelid defects. One of the reasons to write the book was that I had seen many patients in my oculoplastic practice with a history of late diagnoses of malignant eyelid tumors.
Early diagnosis of eyelid malignancies would lead to better patient care, in the majority of cases. The other reason for writing the text was to share my surgical experiences with other surgeons. Many of the texts in print at the time I wrote the first edition listed a variety of repairs for a specific condition. I, however, chose to discuss only those techniques that gave me the best results. The first section contained many pictures of different lesions with descriptions and anecdotal information. It was my belief that the clinician would look at the book as help in diagnosing the eyelid lesion. By comparing the patient’s lesion with the photos in the book, the physician would be in a better position to make a differential diagnosis and continue with the patient’s care. The care might require further testing, a referral, or definitive treatment.
Ophthalmic Oncology (M.D. Anderson Solid Tumor Oncology Series)
By Bita Esmaeli
This book highlights the unique aspects of oncologic ophthalmology as a medical and surgical discipline practiced at a comprehensive cancer center. Multi-disciplinary management of ocular, orbital and adnexal cancers are highlighted using simple and tried-and-true algorithms. In addition, ocular problems caused as a direct result of cancer treatment are reviewed using illustrative photographs and case presentations. The content is provided by full-time ophthalmology faculty and fellows at M. D. Anderson Cancer Center. Experts in complementary disciplines such as ophthalmic pathology, dermatopathology, radiation oncology, radiology, and other surgical subspecialties have brought their unique perspective to each chapter.
The book is abundant with clinical photographs as well as interesting case presentations that will help the clinician correctly diagnose cancers of the orbit, eye, and adnexal structures, initiate appropriate management, as well as recognize and treat common ocular complications of cancer therapy.
Written by internationally renowned authorities, this book provides expert guidance and advice on the diagnosis and management of the complete range of ocular cancers-including eyelid, conjunctival, intraocular, and orbital tumors. From basic principles through the diagnosis and management of every cancer type, it equips you with the state-of-the-art knowledge you need to identify these cancers early and treat them as effectively as possible. More than 800 full-color photographs and illustrations facilitate diagnosis, and a consistent, user-friendly format expedites reference. Plus, a bonus CD-ROM enables you to incorporate any of the book’s figures into your PowerPointÂ® presentations!
Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, from basic principles through clinical features, pathology and diagnostic imaging findings, diagnosis, and differential diagnosis, as well as today’s full range of management options.
Verify your diagnostic conclusions by comparing your findings to more than 800 clinical photographs from the authors’ private collections, histopathologic microphotographs, imaging studies, and crisp illustrations.
Locate the information you need quickly thanks to a practical, clinically focused format.
Essential reading for both medical students and academics in the fields of ophthalmology, neurology and oncology, this is the first textbook to cover the subject of primary intraocular lymphoma (PIOL). The book serves to educate ophthalmologists, neurologists and oncologists on a disease process that is often difficult to diagnose. To help readers recognize the malignancy, a presentation of common and less frequently occurring clinical manifestations of the disease is given. The book provides ophthalmologists the guidelines on current diagnostic and therapeutic modalities as well as the historical background of PIOL.
Survival rates in cases of uveal melanoma and retinoblastoma – the leading intraocular malignancies in adults and children – may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger and promote the two most common ocular tumours.