Retinal and Choroidal Manifestations of Selected Systemic Diseases

 by    J. Fernando Arevalo


Infections with bartonellosis, lyme, and syphilis are not uncommon, especially in selected populations of patients who are at risk. Ocular manifestations, which include retinal and choroidal diseases, are protean and may be initial presentations of the infections or may represent extension of the systemic infectious processes. The diagnosis is often established clinically, with serologic evaluations performed for confirmation. Therapy is targeted with specific anti-infectious agents aiming directly at the underlying infectious organisms. Systemic corticosteroid may be used subsequently to provide complementary control of the inflammation. Ocular involvements, similar to central nervous system disease, mandate intravenous administration of therapeutic agents over sufficient treatment duration.
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Hereditary Retinopathies: Progress in Development of Genetic and Molecular Therapies

Hereditary Retinopathies: Progress in Development of Genetic and Molecular Therapies (SpringerBriefs in Genetics)
Pete Humphries (Author), Marian M. Humphries (Author), Lawrence C. S. Tam (Author), G. Jane Farrar (Author), Paul F. Kenna (Author), Matthew Campbell (Author), Anna-Sophia Kiang (Author)

Book Description
Publication Date: August 4, 2012 | ISBN-10: 1461444985 | ISBN-13: 978-1461444985 | Edition: 2012
The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.

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Corneal Disease: Recent Developments in Diagnosis and Therapy

Thomas Reinhard (Editor), Frank Larkin (Editor)


Book Description
Publication Date: September 28, 2012 | ISBN-10: 3642287468 | ISBN-13: 978-3642287466 | Edition: 2013
This book, written by leading clinicians and scientists, focuses on recent clinically relevant advances in the diagnosis and treatment of corneal disorders. After an opening chapter considering the latest knowledge on the heredity of keratoconus, important advances in corneal imaging are discussed, in particular the use of optical coherence tomography and in vivo confocal microscopy for evaluation of the normal and the diseased cornea. Antiangiogenic treatment options are then reviewed, and new aspects in the diagnosis and therapy of mycobacterial keratitis explained. Further chapters address the storage of donor cornea for penetrating and lamellar keratoplasty and the keratoplasty in infants. The book closes by discussing new developments in antibacterial chemotherapy for bacterial keratitis.

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